APOE and Alzheimer disease: Moreover, several rs-fMRI studies in Apolipoprotein E ε4-positive AD patients reported higher FC of the bilateral dorsolateral prefrontal cortex (part of the DAN) following donepezil therapy (Zaidel et al., 2012) and higher FC of the DAN, the control network, and SN after AchEI treatment than that of untreated AD patients (Wang et al., 2014).