NFKB1 and ulcerative colitis: In agreement with this data, physalin B, when tested in a mouse model of acute colitis-induced by dextran sulfate sodium (DSS), also suppressed the NF-κB cascade by reducing the p-NF-kB p65 and p-iκβα, leading to alleviation of the symptoms and pathological features of ulcerative colitis (Zhang et al., 2020).