And attenuated ANIT-induced hepatotoxicity and cholestasis in rats by inhibiting OATP2 protein, while activating FXR, PXR and SHP receptor protein expression and reducing the regulation of basolateral bile acid uptake, thereby ameliorating cholestasis in model rats (Zhang et al., 2013b; Wang et al., 2017). The gene discussed is NR1I2; the disease is cholestasis.