The M2-like phenotype typical for TAMs is induced by Th2-derived cytokines among which IL-13 plays a central role (Sinha et al., 2005; Jayasingam et al., 2019); therefore, targeting IL-13 receptors/ligands in the tumor microenvironment can inhibit M2 polarization and ultimately reduce tumor burden (Okamoto et al., 2019; Duan and Luo, 2021). This evidence concerns the gene IL13 and neoplasm.