Thus, IL-13-functionalized LCL-SIM specifically targeted the pro-angiogenic functions of TAMs, downregulated the expression levels of major proangiogenic proteins (VEGF, leptin, FasL) and further sensitized the tumor microenvironment to the cytotoxic effects of PEG-EV-DOX manifested via Bax-induced pro-apoptotic status and oxidative stress. Here, LEP is linked to neoplasm.