IL13 and melanoma: In contrast, the monomeric IL-13Rα2 receptor is mostly absent in normal tissues, it is overexpressed in melanoma and other solid tumors, and it constitutes a “private chain” for high-affinity binding and sequestration of IL-13, serving as a potential target for counteracting melanoma progression (Suzuki et al., 2015; Okamoto et al., 2019; Gupta et al., 2021).