LEP and melanoma: This was based on strong inhibitory actions (>90%) on VEGF (major angiogenesis coordinator), FasL (inducer of anticancer T-cell apoptosis at the vascular border), and leptin (stimulator of angiogenesis and overall accelerator of melanoma growth) (Figures 4, 5A,C; Table 4) (Apte et al., 2019; Su et al., 2020).