Tumor cell-derived diffusible molecules and transport vesicles can recruit and polarize TAMs and other immune cells to promote pro-angiogenic signaling pathways via a wide range of molecules such as bFGF, VEGF, IL-1, IL-8, TNF-α, MMPs, and NO (Pan et al., 2020; SenGupta et al., 2021). This evidence concerns the gene VEGFA and neoplasm.