IL13 and melanoma: Moreover, the co-culture between melanoma cells and IL-13-LCL-SIM-treated M2 macrophages rendered B16.F10 melanoma cells more susceptible to the antiproliferative effects of PEG-EV-DOX (Figure 2B), which was also confirmed by the 2-fold decrease in the IC50 of PEG-EV-DOX-treated B16.F10 proliferation in the presence of IL-13-LCL-SIM treated TAMs (Table 3).