In addition, the expression level of the CD31 marker of endothelial cell proliferation was also strongly inhibited (Figures 5A,B) and the macrophage density in melanoma tissue was significantly reduced in both IL-13-LCL-SIM and combination therapy groups, indicating an IL-13-LCL-SIM-mediated suppression of angiogenesis-promoting function of TAMs (Figures 5A,D). Here, PECAM1 is linked to melanoma.