Our data showed that the IL-4 polarized M2 macrophages, which express a phenotype similar to the “M2-like” phenotype of TAMs (Ge and Ding, 2020), were the most efficient in taking up the IL-13-LCL in vitro, compared to M1 (antitumoral) macrophages and to B16.F10 melanoma cells (Figure 1). Here, IL4 is linked to melanoma.