Although melanoma cells can upregulate their antioxidant scavenging capacity to counteract oxidative stress, resulting in redox metabolic adaptation (Arslanbaeva and Santoro, 2020), our data suggest no increase in enzymatic and non-enzymatic antioxidant mechanisms as a response to the pro-oxidant state induced by IL-13-LCL-SIM and PEG-EV-DOX (Supplementary Figure S3). The gene discussed is IL13; the disease is melanoma.