HIF1A and neoplasm: Using an in vitro melanoma model under hypoxia-mimicking conditions (Rauca et al., 2018), it was reported that simvastatin in combination with a vascular disrupting agent induced an unfavorable microenvironment for B16.F10 cell proliferation and migration by suppressing HIF-1α protein levels in tumor cells and downregulating the expression of Arg-1 in TAMs.