Our data revealed that 5 mg/kg SIM encapsulated in IL-13-LCL-SIM elicited the strongest inhibitory effect on B16.F10 melanoma growth compared to the effects of the same concentration of SIM encapsulated in LCL-SIM (by 55% inhibition, p < 0.05) and to free SIM (by 68% inhibition, p < 0.01) (Figure 3A). Here, IL13 is linked to melanoma.