The research on human non-small-cell lung cancer revealed that tumor cell metastasis and invasion were repressed by miR-220c through targeting USP25 [14], which was constant with present study outcomes that the invasion, migration, and proliferation of U251 and U87 glioma cells could be inhibited and promoted by the knockdown and overexpression of USP25, respectively. Here, USP25 is linked to non-small cell lung carcinoma.