Under oxidative stress, NLR family pyrin domain containing 3 (NLRP3) inflammasome can be activated through Drp1 hyperactivation and glycolysis inhibition in mature oligodendrocytes, which can contribute to AD-associated neuropathology (Luo et al., 2017; Zhang et al., 2020). The gene discussed is NLRP3; the disease is Alzheimer disease.