Mitochondria-related dysfunction is also involved in PD, mainly through respiratory chain impairment, mitochondrial DNA (mtDNA) alterations, and dysregulation of mitophagy, through mutations in Parkin and PTEN-induced kinase 1 (PINK1) in familial PD (Monzio Compagnoni et al., 2020). The gene discussed is PRKN; the disease is Parkinson disease.