MAPT and Alzheimer disease: LA is an antioxidant that can also function as the co-enzyme for mitochondrial pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, and its supplementation can effectively inhibit tau hyperphosphorylation, caspase-dependent apoptosis, peroxidation, and inflammation in tau P301S transgenic mouse models of AD (Zhang et al., 2018).