HOMER1 and Parkinson disease: Regarding PD treatment, the in vitro application of SKF-96365, a non-specific inhibitor of SOCE, reduced intracellular Ca2+ overload and inhibited homer1-mediated ER Ca2+ release in a PC12 cell model of neurotoxin N-methyl-4-phenylpyridinium [MPP(+)]-induced PD (Chen et al., 2013).