Dilated cardiomyopathy is the hallmark of classical laminopathies, as demonstrated in recent studies of Captur et al. (37), who reviewed Lamin A/C heart disease and showed that DCM occurred in 10% of LMNA carriers, up to 5% in patients with sporadic idiopathic DCM, 5–10% with idiopathic familial DCM, and 33% with familial DCM and cardiac conduction system disease. This evidence concerns the gene LMNA and familial dilated cardiomyopathy.