In order to provide large sample data to explore the significance and value of PD-L1 as a predictive factor of CRC, this study combined published research data on PD-L1 expression and PROGNOSIS of CRC with the method of meta-analysis, and evaluated the prognostic significance of PD-L1 expression and related clinicopathological parameters in CRC. This evidence concerns the gene CD274 and colorectal carcinoma.