In this study, the HE4, IL-33, and CA153 levels in patients were obviously higher in the MG than those in the BG (P < 0.05) and were significantly higher in the BG than those in the CG (P < 0.05), implying that serum HE4, IL-33, and CA153 markers have certain value in early screening of cervical cancer and can reflect patients' condition. This evidence concerns the gene WFDC2 and cervical cancer.