Its analgesic mechanism may be involved in the following mechanisms: (1) The mechanosensitive channel TRPV1 involved in acupuncture-related analgesia is highly expressive at ST36 [101]; acupuncture at ST36 attenuated cancer-induced pain by inhibiting the upregulation of TRPV1 mRNA and protein in DRGs [102]. The gene discussed is TRPV1; the disease is cancer.