TLR4 and Cerebral ischemia: EA at Quchi (LI11) and Zusanli (ST36) had a neuroprotective effect against ischemic stroke, by inhibiting TLR4/NF-κB-mediated inflammation [51]; EA at DU20 and DU24 improved cognitive impairment in rats with cerebral ischemia-reperfusion by upregulating Bcl-2 and downregulating Bax to counteract apoptosis [52].