TGFB1 and glomerulosclerosis: In addition, resveratrol can also deacetylate Sma2/3 to inhibit the activity of the TGFβ-Smads pathway, reduce renal interstitial fibrosis and glomerular sclerosis, restore the expression of Nephrin and Podocin in diabetic nephropathy rats, and protect podocytes [36].