BECN1 and diabetic kidney disease: Similarly, our study found that the expression of LC3-I/II and Beclin1 protein in the DN group was significantly decreased, and P62 was increased; that is, DN inhibited autophagy; and Tang-Shen-Jian upregulated the autophagy activity of podocytes after intervention and reduced podocyte damage so as to play a protective effect on the kidneys of diabetic nephropathy rats, which is consistent with the above research conclusions.