HIF1A and brain ischemia: Some studies clearly showed that HIF-1α exerts a neuroprotection role by correlating with the expression of target genes involved in various adaptive responses in cerebral ischemia [25, 55], while other experimental studies demonstrated that HIF-1α played a harmful effect by activating the expression of multiple prodeath genes after stroke, and the HIF-1α inhibition was beneficial [77, 78].