Estrogen and selective agonist for each subtype of ER, such as ERα agonist, 4,4′,4′′-(4-propyl-(1H)-pyrazole-1,3,5-tryl) triphenol and ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile [DPN]) regulates the axonal guidance molecules of the SLIT/ROBO signaling that have a critical role in neuroangiogenesis occurring in endometriosis lesions found on the peritoneal wall (50). The gene discussed is ESR1; the disease is endometriosis.