The results showed that high expression of CDCA8 was associated with poor OS (HR = 5.08, 95% confidence interval (CI) = 1.21-21.28, P = 0.026) and poor DFS (HR = 2.31, 95% CI = 1.49-3.58, P < 0.001) in PCa patients. Here, CDCA8 is linked to posterior cortical atrophy.