CD274 and neoplasm: LMP1 was considered as the most important oncoprotein of EBV-related proteins, which regulates NF-κB, Phosphatidylinositol-3-kinase (PI3K), JAK-STAT, and other signaling pathways and mediates proliferation, invasion, and metastasis of ENKTL tumor cells by upregulating expression of PDL1 (38, 39).