High expression of FRMD4A is associated with an increased risk of HNSCC recurrence, and the silencing of FRMD4A inhibits the growth and metastasis of human squamous cell carcinoma in skin and tongue metastases and reduces the proliferation and cell adhesion of squamous cell carcinoma (82, 83). The gene discussed is FRMD4A; the disease is head and neck squamous cell carcinoma.