ASH1L and Anxiety: First, consistent with the observation that the Ash1l mutant mice had longer running distances in the open field test (Gao et al., 2021), the 72-h locomotor activity measurement showed that compared to wild-type controls, the Ash1l mutant mice had more active movement and longer running distances in their home cages (Figure 1), suggesting that the locomotor hyperactivity of Ash1l mutant mice was likely to be an outcome of Ash1l loss in the brain but not due to increased anxiety in the open field test chamber.