To examine the relationship between disruptive ASH1L mutations and ASD genesis, we recently used an Ash1l conditional knockout mouse model to show that loss of Ash1l in the mouse brain was sufficient to induce ASD/ID-like behavioral and cognitive deficits, suggesting disruptive ASH1L mutations are likely to have a positive correlation with some core symptoms of ASD (Gao et al., 2021). The gene discussed is ASH1L; the disease is Cognitive impairment.