MMP2 and neoplasm: Studies have found that the oxLDL/LOX-1 activates the NF-κB signaling pathway through a variety of pathways, regulates the transcription of a variety of genes, and induces the increased expression of VEGF, MMP-2, and MMP-9, thereby promoting tumor growth, migration, and invasion through effective blood vessels [7, 23, 25, 35, 36].