Like the proximity score, high density score was associated with proximal tumour location (P = 0.003), low disease stage (P = 0.0002), absence of lymphovascular invasion (P = 0.0004), MMR deficiency (P < 0.0001) and BRAF mutation (P = 0.001; Table S3). This evidence concerns the gene BRAF and hyperinsulinemic hypoglycemia, familial, 4.