An example of a changed diagnosis includes the re-classification of a pleomorphic xanthoastrocytoma (P2830) to an infant-type hemispheric glioma [9], generated by an intrachromosomal deletion on chromosome 2p adjoining exons 1–12 of the CCDC88A gene with ALK exons 20–29 reported previously [10]. Here, ALK is linked to central nervous system cancer.