Wild-type human PS1 (wt hPS1) was able to rescue the ferroptosis susceptibility phenotype to near WT MEF values, but PS dKO cells expressing either of two different familial AD mutant forms of PS1 (L166P and I213T) remained more sensitive to ferroptosis (Fig. 1c, d), consistent with impaired function. Here, PSEN1 is linked to Alzheimer disease.