To fully understand the effect of HtrA2/Omi on hepatic steatosis and related metabolic disorders, we further set up hepatic HtrA2/Omi-overexpressed mice models through tail-vein injections of AAV8-TBG-mNeongreen-HtrA2/Omi (Fig. 2A). The gene discussed is SERPINA7; the disease is Hepatic steatosis.