On the one hand, knockout of YTHDF2 in LCSCs reduces the m6A level in the 5’-untranslated region of OCT4 mRNA and then reduces the expression of the OCT4 protein, a pivotal transcription factor modulating the stemness and malignant development of liver cancer [39] On the other hand, YTHDF2 promotes m6A-mediated mRNA degradation of suppressor of cytokine signaling 2 (SOCS2, a cancer-suppressive factor). This evidence concerns the gene POU5F1 and liver cancer.