Vinciguerra et al. successively demonstrated the silencing of macroH2A1, a histone H2A variant, inducing a stem cell-like phenotype of HCC cells characterized by a lipidomic signature with increased levels of total sphingomyelin and decreased levels of total lysophosphatidylcholine [48]; moreover, single-cell RNA-sequencing and metabolomic analysis has shown that the phospholipid synthesis pathway is significantly enriched in HCC. The gene discussed is MACROH2A1; the disease is hepatocellular carcinoma.