In contrast, when the function of mitophagy is impaired, p53 phosphorylated by PINK1 cannot be removed by mitophagy and is transported to the nucleus, where it binds to the NANOG promoter and inhibits the expression of NANOG, a key transcription factor that promotes the self-renewal ability of LCSCs, leading to a reduction in tumor stemness [108]. The gene discussed is NANOG; the disease is neoplasm.