A total of 15 patients in the 8085 Chinese consecutive breast cancer cohort (0.19%) carried a pathogenic germline variant in the four MMR genes, including PMS2 (n = 6), MSH6 (n = 5), MSH2 (n = 3), and MLH1 (n = 1) (Table 1). Here, PMS2 is linked to breast carcinoma.