Notably, mice implanted with the USP22-overexpressing MHCC-97L cells formed larger tumors compared to those implanted with the control MHCC-97L cells; however, MHCC-97L cells with simultaneous USP22 overexpression and PPARγ, ACC or ACLY knockdown showed lower tumor growth rates (Fig. 7g–i). This evidence concerns the gene ACLY and neoplasm.