Furthermore, mice implanted with either the shControl MHCC-97H cells or the MHCC-97H cells with simultaneous USP22 knockdown and PPARγ overexpression showed similar tumor growth rates, whereas mice bearing the USP22-knockdown MHCC-97H cells showed markedly inhibited tumorigenesis (Fig. 7j–l). This evidence concerns the gene PPARG and neoplasm.