To investigate the relevance of our findings to human HCC, we analyzed the expression of USP22, PPARγ, ACC, and ACLY in HCC TMAs (which contains prognosis information) by IHC (Fig. 8a), and found that USP22 expression was positively correlated with PPARγ, ACC or ACLY expression (Fig. 8b). Here, USP22 is linked to hepatocellular carcinoma.