AKT1 and renal cell carcinoma: Additionally, our data indicated that the protein levels of phosphorylated mTOR (p-mTOR) and phosphorylated AKT (p-AKT) were increased after ORP5 overexpression in RCC cells and decreased in ORP5 knockdown cells, which indicated that ORP5 could activate the mTORC1/AKT signaling pathway in RCC cells (Fig. 3A).