SMAD7 and neoplasm: There were no correlations between all studied parameters and clinicopathological characteristics (age, grade, tumor size, metastatic state, family history and Lauren classification) of GC patients except a significant positive correlation of SMAD7 with tumor size and metastatic state (P = 0.008, 0.007 respectively) and a significant negative correlation of SEC13 with family history (P = 0.033).