Then in contrast with the control (sgC), the knockout of SNIP1inhibited the colony formation in vitro (Supplementary Fig. 1i, j), and reduced tumor growth in vivo (Fig. 1f, g) with significantly downregulated Ki67 expression in primary tumor tissues (Fig. 1h, i); while re-expression of wild-type SNIP1 (SNIP1WT) but not the SNIP1K301R mutant significantly restored the ability of cell colony formation (Supplementary Fig. 1i, j), tumor growth (Fig. 1f, g) and Ki67 expression (Fig. 1h, i). The gene discussed is MKI67; the disease is neoplasm.