To find out whether this synergy occurs in vivo, athymic nude mice injected intravenously with MDA-MB-231 cells and Balb/c mice injected orthotopically with 4T1 cells were adopted (Supplementary Fig. 7d); 7 days after inoculation, mice transplanted with MDA-MB-231 and 4T1 with or without KMT5A depletion were treated with either verteporfin (50 mg/kg, i.p.)or vehicle daily for another 14 days; tumor metastasis was monitored at day 21 post-implantation, respectively. The gene discussed is KMT5A; the disease is neoplasm.