In line with these in vitro findings, ectopic of SNIP1K301M, but not SNIP1WT, restored KMT5A depletion-mediated inhibition of proliferation and invasion (Fig. 4d, f) in vitro, as well as tumor growth and lung metastasis in vivo (Fig. 4e, g), and decreased KMT5A depletion prolonged animal survival (Fig. 4h). The gene discussed is KMT5A; the disease is neoplasm.