In the mouse model of amyotrophic lateral sclerosis, a misfolded mutant of superoxide dismutase 1 (SOD1) directly inhibits VDAC1 conductance [12, 13], disclosing the connection of VDAC1 and SOD1 in oxidative stress [14, 15]. This evidence concerns the gene VDAC1 and amyotrophic lateral sclerosis.