The expression of CD274, as well as some EMT markers (SLUG, MMP9), OCT4 and chemokines (IL4, IL13), were up-regulate in GC cells co-cultured with MADCAM1P270Q-reprogrammed or MADCAM1D242N-reprogrammed-TAMs, compared with GC cell co-cultured with MADCAM1WT-reprogrammed-TAMs (Supplementary Fig. 5F). The gene discussed is MMP9; the disease is gastric cancer.