The expression of M2 markers, including ARG1, IL10 and CD163 was higher in MADCAM1P270Q-reprogrammed tumor-associated macrophages (TAMs) and MADCAM1D242N-reprogrammed-TAMs, but lower or same in MADCAM1WT-reprogrammed-TAMs compared with control (Supplementary Fig. 5A). The gene discussed is IL10; the disease is neoplasm.