In conclusion, our study results elucidate that miR-30a-3p intervention affects BC in two manners: [1] by directly targeting ATG5, ATG12, and Beclin 1 to impair cisplatin-induced protective autophagy and leading to slow tumor growth and [2] by reducing the expression of MMP2 and MMP9 in tumors, thus inhibiting cell invasiveness in vitro and muscle invasion in vivo (Fig. 9). This evidence concerns the gene MMP2 and breast cancer.