The protein abundances of ALDH2 (AS: Z-score: 4.372, P = 1.23 × 10−5; AIS: Z-score: 4.712, P = 2.46×10−6) and SLC44A2 (AS: Z-score: − 4.284, P = 1.84×10−5; AIS: Z-score: − 4.396, P = 1.10 × 10−5) were both associated with AS and AIS, and the protein abundances of PTPN11 (Z-score: − 4.484, P = 7.31 × 10-6) and VPS36 (Z-score: − 4.229, P = 2.35 × 10−5) were also associated with AIS (Additional file 1: Table S1 and S2). Here, ALDH2 is linked to androgen insensitivity syndrome.