CDK16 and breast cancer: Consistent with the results from TCGA dataset, Breast Cancer (METABRIC, Nature 2012 & Nature Commun 2016) combined databases [24–26] (Fig. 1E) and GSE76250 dataset (Fig. 1G) also revealed that CDK16 expression was elevated in TNBC compared with normal breast tissues, and the high CDK16 expression was positively correlated with poor clinical outcomes (Fig. 1F).