Intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are cell-surface glycoproteins on endothelial cells and immune cells, mediating the adhesion of leukocytes to endothelial cells and the transport of leukocytes to the brain, and they reperesent another group of interesting markers of inflammation in AD [113]. This evidence concerns the gene ICAM1 and Alzheimer disease.