Hatori [36] has demonstrated that empagliflozin could significantly decrease the inflammation level in T2DM patients and this alteration could be partly attributed to the decrease of remnant lipoprotein, indicating the potential of sodium-dependent glucose transporters 2 (SGLT2) inhibitors in ameliorating the coronary collateral growth and improving the prognosis of those patients. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.