NRF1 and colon adenocarcinoma: The TIMER database showed that NRF1 mRNA expression was significantly higher in CHOL (bladder urothelial carcinoma), COAD (colon adenocarcinoma), KIRC (kidney renal clear cell carcinoma), KIRP (kidney renal papillary cell carcinoma), and LIHC (liver hepatocellular carcinoma), while it was lower in BRCA (breast invasive carcinoma), LUAD (lung adenocarcinoma), UCEC (uterine corpus endometrial carcinoma), PRAD (prostate adenocarcinoma) and THCA (thyroid carcinoma) than in normal tissues (Fig. 1a).