HEPH and alkaline phosphatase measurement: Additionally, DGGR-lipase activity greater than 3× URL had 80% sensitivity and 100% specificity for cPL concentrations considered consistent with AP in critically ill dogs with a variety of primary clinical diseases, including AP, as well as renal disease, immune-mediated and endocrine disorders, and upper airway obstruction, suggesting the limited specificity of both assays [26].