Although the exact mechanism of azole-mediated hair loss is unclear, voriconazole and itraconazole have been found to inhibit CYP26A1-mediated hydroxylation of retinoic acid in vitro at concentrations of >1 μM [44], with alopecia reported due to itraconazole, voriconazole, and posaconazole. The gene discussed is CYP26A1; the disease is alopecia.