FADS2 and asthma: For the one asthma-related metabolite, 1-arachidonoyl-GPA (20:4), one locus of rs28456, an intronic variant of Fatty Acid Desaturase 2 (FADS2), was previously reported in HCHS/SOL that reached genome-wide significance for asthma (beta = 0.16, se = 0.03, p = 6.08 × 10−11, allele frequency of the effect allele A = 0.54) [20].