TTR and Alzheimer disease: Therefore, Man-Tf, together with L-PGDS, TTR, and Tf isoforms in the CSF, was quantified for CN, MCI, and AD subjects (Figure 2) whose MMSE scores (mean ± S.D.)were 29.0 ± 1.6, 26.9 ± 1.7, and 20.4 ± 4.2, respectively.