PLA2G2A and cancer: In addition, several bacteria-specific metabolites such as trigonelline and ectoine, which can affect inflammation and cancer [62], and dicarboxylic acids such as pimelate, sebacate, and azelate, whose levels are associated with the abundance of Ruminococcaceae [63], were reduced in Pla2g2a−/− mice relative to Pla2g2a+/+ mice (Figure 2A).