Indeed, knockout of pancreatic sPLA2-IB, a digestive sPLA2 that degrades dietary and biliary phospholipids in the intestinal lumen [19], impairs the defense against parasite infection in association with the change in gut microbiota [90], although it remains unclear whether this event would be related to the improved atherosclerotic and metabolic phenotypes in Pla2g1b−/− mice [6,91,92]. The gene discussed is PLA2G1B; the disease is parasitic infectious disease.