5-LOX, which facilitates the biosynthesis of LTs and several other eicosanoids, has gained interest as a potential drug target against neuroinflammation because it is widely expressed in the central nervous system (CNS) and co-localizes with Aβ and neurofibrillary tangles in the hippocampal region of AD patients [118]. The gene discussed is ALOX5; the disease is Alzheimer disease.