Mechanistically highly relevant examples of these include the following pathways: glioblastoma signaling; brain-derived neurotrophic factor (BDNF) signaling; microRNA targeting; VEGFA-VEGFR2; MAPK; EGF-EGFR; integrin-mediated adhesion; cell cycle; mitotic G1/S and G2/M phases; TNFα; DNA damage response; hepatocyte growth factor, Vitamin D and FGF receptors; JAK/STAT; IL6; IL11; IL2; IL5; TGFβ; TP53 and cell death genes; apoptosis execution phase; multiple hormonal and developmental pathways. The gene discussed is BDNF; the disease is glioblastoma.