This impairment in insulin stimulation of liver GU measured by 18F-FDG-PET, which indicates decreased hepatic glucokinase activity, is in line with research showing lower UDP-flux during hyperinsulinaemia with intravenous or enteral glucose delivery [84,85] and postprandial glycogen synthesis rate [86] in patients with T2DM. This evidence concerns the gene INS and type 2 diabetes mellitus.