The main finding of this work is that, in a swine model of hyperdynamic septic shock without overt signs of heart failure, elevated values of circulating cTnT were present within a couple of hours of shock onset in a subset of septic pigs and the hs-cTnT level was found to be associated with metabolites that may be related to collagen metabolism. This evidence concerns the gene TNNT2 and heart failure.