OGT and pulmonary arterial hypertension: We recently showed that alterations in glucose uptake and flux into the HBP led to augmented OGT expression/activity, increased proliferation in IPAH pulmonary artery smooth muscle cells (PASMCs), and faster time to clinical worsening in PAH (as defined by hospitalization, lung transplantation, or death; n = 86 PAH patients) [139].