While some studies including patients with active acromegaly found that intrahepatic lipid, measured by magnetic resonance spectroscopy, is relatively low in comparison to healthy subjects [20,45], others showed that hepatic steatosis is a common comorbidity in acromegaly, hypothesizing that lipotoxicity and insulin resistance may outweigh the direct hepatic effects of GH [46]. This evidence concerns the gene GH1 and Hepatic steatosis.