MAPT and Alzheimer disease: The issue at stake in MMC residents relates to Braak and Del Tredeci et al.’s key papers on AD and PD development: “Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads, neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic Alzheimer’s disease.