In an autopsy cohort of 203 MMC previously clinically healthy individuals (age 25.36 ± 9.23 years), all, except a 22 year-old female with a TLR4 Asp299Gly polymorphism, showed AD neuropathology hallmarks, as defined by the presence of hyperphosphorylated tau protein (p-τ) and amyloid ß 17–24 [10]. The gene discussed is MAPT; the disease is Alzheimer disease.