TARDBP and Alzheimer disease: The targeted predominantly anterior brain atrophy is critical, since we have shown extensive cortical and brainstem progressive proteinopathies associated with AD, PD and TDP-43 pathology and neuroinflammation in 203 consecutive forensic autopsies of MMC ≤ 40 years old individuals, and clinically abnormal brainstem auditory evoked potentials (BAEPs), stress and sleep behaviour disorders, gait and equilibrium abnormalities, and CSF and brain MRS AD markers in pediatric and young adult ages [1,2,75,91,92,93,94,95,96,97].