Moreover, of deep concern is the fact that in Aβ-positive elderly [121], 16% of variance in cross-sectional cognitive impairment was accounted for by Aβ, 46–47% by tau, and 25–29% by atrophy, and the Aβ-tau-atrophy pathway accounted for 50% to 56% of variance in longitudinal cognitive decline [121]. This evidence concerns the gene MAPT and Atrophy.