MAPT and Cognitive impairment: Specifically, we know that 55% of the MMC population (average age 21.6 ± 5.8 years, with 13.7 ± 1.3 formal education years) is already cognitively impaired, but we are very aware it will be extremely difficult to apply the ATN biomarker classification system (amyloid beta [A], pathologic tau [T], and neurodegeneration [N]) for predicting conversion from mild cognitive impairment (MCI) to dementia [118,119,120].