PICALM and Alzheimer disease: AD-related endocytic genes identified correspond, among others, to the CME-linked phosphatidylinositol-binding clathrin assembly protein (PICALM) [63], CME-linked AP2A1 and AP2A2 [64], CME/FEME-linked bridging integrator 1 (BIN1)/amphiphysin 2 [65], CME-related cortactin-CD2-associated protein (CD2AP) [66], and CME and UFE-related synaptojanin protein [67].